Tuesday, September 5, 2017

Know Your Terpenoids : Myrcene




From what we've learned in my previous articles, it has been made clear that when selecting a strain - look towards the terpenes profiles.  This next terpene is viewed as an effective analgesic, anti-bacterial, anti-diabetic, anti-inflammatory, anti-insomniatic, anti-proliferative, antipsychotic, and anti-spasmodic.

Myrcene is a monoterpene, the smallest of the terpenes, and is found in very high concentrations in sweet basil, mangoes, hops, and cannabis.   Hops and cannabis are in fact cousins, both members of the family Cannabaceae.  Myrcene  name originates from Myrcia sphaerocarpa, a medicinal shrub from Brazil that contains very high amounts of myrcene which has been used there as a folk remedy for diabetes, diarrhea, dysentery, and hypertension for ages.  

While possessing earthly, fruity, cloves-like aromas, myrcene has been shown to change the permeability of cell membrane to allow more absorption of cannabinoids by the brain.  Myrcene is pivotal in the formation of other terpenes and it synergies the antibiotic potential of other terpenes. Conducted in Switzerland, a 1997 study analyzed various cannabis strains for 16 terpenes and found myrcene to be the most abundant terpene out of those studied. For some strains, the myrcene profile can be over half the total content. Other found abundant terpenes include PineneLimonene, Linalool, Carene, Humulene, Bergamotene, Terpinolene, and Caryophyllene.  


Myrcene :




Formula : C10H18 O

Molecular Mass : 136.23404 g/mol

Decarboxylation Point : 115-145 °C(239 °F to 293 °F)

Boiling Point : 168 °C (334 °F)

Vapor Pressure : 7.00 mmHg  (20 °C)




Aroma : Musky, cloves, earthy, herbal with hints of citrus and tropical fruits 



Effects : Sedation, relaxation



Medical Value : Antioxidant, Anti-Carcinogenic, Anti-Inflammatory, Anti-Depressant; good for muscle tension, sleeplessness, and chronic pain.   



Also Found In : Mango, lemongrass, cloves, thyme, hops 



Known Strains High in Myrcene : Pure Kush, El Nino, Himalayan Gold, Skunk #1, White Widow, Grand Daddy Purple GDP



Other Known Factoids : The effects of myrcene has been studied since the 1970s and around the year 2010 a rumor spawned that eating a ripe mango before smoking cannabis would increase the effects or "get you higher."  Recent information published by Steep Hill Labs, a well-known medical marijuana testing laboratory located in the Bay Area of California, "most people eating a fresh mango 45 minutes before inhaling cannabis will increase the effects of that cannabis." The man behind this study, Rev. Dr. Kymron de Cesare of Steep Hill, is an advocate of what he has named the "overlapping synergies" between myrcene and other terpenes with various cannabinoids, one of them being how myrcene makes THC more effective. 




** IMPORTANT NOTE :  Each batch is subject to variable growing conditions, meaning NOT every batch of any given strain will have high levels of these terpenes.  The only way to be certain is through a lab's terpene analysis found on label of patients prescription.


Therapeutic attributes of Myrcene :

Analgesic - Relieves pain.

Anti-Bacterial - Slows bacterial growth.

Anti-Diabetic - Helps mitigate the effects of diabetes.

Anti-Inflammatory - Reduces inflammation systemically.

Anti- Insomnia - Helps with sleep.

Anti-Proliferative/Anti-Mutagenic - Inhibits cell mutation- including cancer cells.

Antipsychotic - Tranquilizing effects relieve symptoms of psychosis.

Antispasmodic - Suppresses muscle spasms.





Commonly found in higher concentrations in strains:

Pure Kush

 El Nino

 Himalayan Gold

 Skunk #1

 White Widow

 Grand Daddy Purple GDP




Summary Of Case Studies Done On Myrcene

Studies :

- The University of Jordan , located in Amman, Jordan, was the research university to investigate Myrcene as the "folk remedy" known cure for diabetes.  This 2007 pilot study done on mice convincingly showed that myrcene and also another terpene, thujone, both had a hand in mitigating the effects of diabetes. Of course, further research is needed to better understand the mechanisms of action.

- Myrcene's analgesic effects have been known since the 1990s when a pair of studies demonstrated the pain-relieving power of this terpene. study done in 1990 found the analgesic effects of myrcene and its unique ability to stimulate the release of endogenous opiates in the body, allowing for pain reduction without any need of external opiate pills.  This 1991 study by Lorenzetti Et Ai showed that myrcene demonstrated strong sedative effects and to be promising enough to become a new class of aspirin-like drugs that used a completely different channel in the body.  A later 2002 study re-examined and reinforced myrcene showing it to produce barbiturate-like sedative effects in mice in very high doses.  It was also shown that these effects increased if citral, a mixture of other terpenes, was present as well.

- This 1990 study , conducted by Da Sila et Ai, sought out to analyze the neurobehavioral effects of myrcene on mice.  Despite having strong analgesic and sedative effects, they found that it had NO impact on reducing anxiety, depression, or psychosis.  Actually it was documented in the Journal of Phytomedicine (2002),  it was found that at high doses myrcene can actually increase anxiety, rather than reduce it.

- In this 2010 studyThe National Toxicology Program found "equivocal evidence that beta-myrcene was carcinogenic."  This study prompted The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) to propose listing beta-myrcene as a cancer causing compound under the Safe Drinking Water and Toxic Enforcement Act of 1986. *Not enough scientific research has been done to list beta-myrcene as potentially carcinogenic. 


To properly maximize the medicinal benefits of this terpene and to learn the science behind "Cooking With Cannabis", be sure to DOWNLOAD...

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SOURCES :

www.pubchem.com
www.pubmed.com
www.theleafonline.com
https://www.leafly.com/news/cannabis-101/terpenes-the-flavors-of-cannabis-aromatherapy
https://www.spectrumchemical.com/MSDS/M0070.PDF
https://en.wikipedia.org/wiki/Myrcene
http://www.internationalhempassociation.org/jiha/jiha4208.html
http://steephill.com/science/terpenes
https://unitedpatientsgroup.com/blog/2012/04/11/terpene-and-cannabis-by-rev-dr-kymron-de-cesare-of-halent-laboratories
http://theleafonline.com/c/science/2014/09/terpene-profile-myrcene/
https://www.ncbi.nlm.nih.gov/pubmed/1753786
https://www.ncbi.nlm.nih.gov/pubmed/1983154
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
https://www.ncbi.nlm.nih.gov/pubmed/12587690
https://www.ncbi.nlm.nih.gov/pubmed/1753786
https://www.ncbi.nlm.nih.gov/pubmed/1797273
https://www.ncbi.nlm.nih.gov/pubmed/12587690
https://oehha.ca.gov/proposition-65/crnr/notice-intent-list-beta-myrcene
https://en.wikipedia.org/wiki/Terpenoid

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Birth name Danielle Russell, friends and colleagues call her Dee.  Dee has been making medibles or medicinal edibles with cannabis from 2006 to present.  In 2014 she published the first edition of her cannabis cookbook, The Happy Chef THC, including hip-hop album “The Prescription” from hip-hop artist and MMJ patient B-Real of Cypress Hill. The year 2015 was the year of legalization for medical marijuana for the state of Nevada.  Dee worked as a Canna Chef in the first licensed MMJ Production Kitchen in the state of Nevada located in the fabulous city of Las Vegas - she still continues to make her edibles for the patients in the state today.

Are edibles not your thing?  Maybe you had a bad edible cannabis experience?  Eat too much or not enough - trouble dosing?  Or - perhaps you enjoy cooking with the plant and/or have an interest in joining the cannabis industry as a Canna Chef in an MMK Production Lab.  In with case, HER LATEST CANNA COOKBOOK IS THE ONE YOU NEED!!  Check out her latest EXPERT CANNABIS COOKBOOK - Deliciously Dee The Happy Chef Expert Cannabis Cookbook.  (available on Amazon & iBooks)